{"id":14741,"date":"2023-03-01T11:01:52","date_gmt":"2023-03-01T04:01:52","guid":{"rendered":"https:\/\/www.thegioimaychu.vn\/blog\/?p=14741"},"modified":"2023-03-01T15:06:08","modified_gmt":"2023-03-01T08:06:08","slug":"ai-dang-bien-doi-he-gen-hoc-nhu-the-nao","status":"publish","type":"post","link":"https:\/\/thegioimaychu.vn\/blog\/ai-hpc\/ai-dang-bien-doi-he-gen-hoc-nhu-the-nao-p14741\/","title":{"rendered":"AI \u0111ang l\u00e0m thay \u0111\u1ed5i ng\u00e0nh Gen h\u1ecdc nh\u01b0 th\u1ebf n\u00e0o?"},"content":{"rendered":"<style>.iblink{color:#975!important;}.iblink:hover{color:orange!important;}<\/style><p><em><strong><a class=\"iblink\" href=\"\/blog\/tag\/ai\/\">Tr\u00ed tu\u1ec7 nh\u00e2n t\u1ea1o<\/a> (AI) v\u00e0 \u0111i\u1ec7n to\u00e1n t\u0103ng t\u1ed1c \u0111ang m\u1edf ra nh\u1eefng kh\u1ea3 n\u0103ng m\u1edbi trong quy tr\u00ecnh gi\u1ea3i tr\u00ecnh t\u1ef1 gen.<\/strong><\/em><\/p>\n<p>Nh\u1eefng ti\u1ebfn b\u1ed9 trong gi\u1ea3i tr\u00ecnh t\u1ef1 to\u00e0n b\u1ed9 gen (whole genome sequencing) \u0111\u00e3 ch\u00e2m ng\u00f2i cho m\u1ed9t cu\u1ed9c c\u00e1ch m\u1ea1ng trong Sinh h\u1ecdc k\u1ef9 thu\u1eadt s\u1ed1.<\/p>\n<p>C\u00e1c ch\u01b0\u01a1ng tr\u00ecnh h\u1ec7 gen h\u1ecdc tr\u00ean kh\u1eafp th\u1ebf gi\u1edbi \u0111ang tr\u00ean \u0111\u00e0 ph\u00e1t tri\u1ec3n khi chi ph\u00ed d\u00e0nh cho gi\u1ea3i tr\u00ecnh t\u1ef1 th\u1ebf h\u1ec7 ti\u1ebfp theo, th\u00f4ng l\u01b0\u1ee3ng cao \u0111\u00e3 gi\u1ea3m xu\u1ed1ng.<\/p>\n<p>Cho d\u00f9 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u1ea3i tr\u00ecnh t\u1ef1 \u0111\u1ed1i v\u1edbi\u00a0<a href=\"https:\/\/blogs.nvidia.com\/blog\/2022\/02\/18\/guinness-world-record-fastest-dna-sequencing\/\" target=\"_blank\" rel=\"noopener\">c\u00e1c b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ch\u0103m s\u00f3c \u0111\u1eb7c bi\u1ec7t m\u1eafc c\u00e1c b\u1ec7nh hi\u1ebfm g\u1eb7p<\/a>\u00a0hay trong\u00a0<a href=\"https:\/\/blogs.nvidia.com\/blog\/2022\/01\/26\/uk-biobank-advances-genomics-research-clara-parabricks\/\" target=\"_blank\" rel=\"noopener\">nghi\u00ean c\u1ee9u di truy\u1ec1n quy m\u00f4 d\u00e2n s\u1ed1<\/a>, gi\u1ea3i tr\u00ecnh t\u1ef1 to\u00e0n b\u1ed9 gen \u0111ang tr\u1edf th\u00e0nh m\u1ed9t b\u01b0\u1edbc n\u1ec1n t\u1ea3ng trong quy tr\u00ecnh l\u00e0m vi\u1ec7c l\u00e2m s\u00e0ng v\u00e0 ph\u00e1t tri\u1ec3n thu\u1ed1c.<\/p>\n<p>Nh\u01b0ng gi\u1ea3i tr\u00ecnh t\u1ef1 gen ch\u1ec9 l\u00e0 b\u01b0\u1edbc \u0111\u1ea7u ti\u00ean.\u00a0Ph\u00e2n t\u00edch d\u1eef li\u1ec7u gi\u1ea3i tr\u00ecnh t\u1ef1 gen y\u00eau c\u1ea7u \u0111i\u1ec7n to\u00e1n t\u0103ng t\u1ed1c, khoa h\u1ecdc d\u1eef li\u1ec7u v\u00e0 AI \u0111\u1ec3 \u0111\u1ecdc v\u00e0 hi\u1ec3u b\u1ed9 gen.\u00a0V\u1edbi\u00a0<a href=\"https:\/\/venturebeat.com\/games\/jensen-huang-qa-why-moores-law-is-dead-and-smart-design-is-replacing-it\/\" target=\"_blank\" rel=\"noopener\">s\u1ef1 k\u1ebft th\u00fac c\u1ee7a \u0111\u1ecbnh lu\u1eadt Moore<\/a>, theo quan s\u00e1t cho th\u1ea5y r\u1eb1ng s\u1ed1 l\u01b0\u1ee3ng b\u00f3ng b\u00e1n d\u1eabn trong m\u1ed9t IC s\u1ebd t\u0103ng g\u1ea5p \u0111\u00f4i c\u1ee9 sau hai n\u0103m, c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec7n to\u00e1n m\u1edbi l\u00e0 c\u1ea7n thi\u1ebft \u0111\u1ec3 gi\u1ea3m chi ph\u00ed ph\u00e2n t\u00edch d\u1eef li\u1ec7u, t\u0103ng th\u00f4ng l\u01b0\u1ee3ng v\u00e0 \u0111\u1ed9 ch\u00ednh x\u00e1c c\u1ee7a c\u00e1c l\u1ea7n \u0111\u1ecdc v\u00e0 cu\u1ed1i c\u00f9ng l\u00e0 m\u1edf kh\u00f3a to\u00e0n b\u1ed9 ti\u1ec1m n\u0103ng c\u1ee7a b\u1ed9 gen ng\u01b0\u1eddi.<\/p>\n<h2>B\u00f9ng n\u1ed5\u00a0d\u1eef li\u1ec7u\u00a0Tin sinh h\u1ecdc<\/h2>\n<p>Gi\u1ea3i tr\u00ecnh t\u1ef1 to\u00e0n b\u1ed9 gen c\u1ee7a m\u1ed9t c\u00e1 nh\u00e2n t\u1ea1o ra kho\u1ea3ng 100GB d\u1eef li\u1ec7u th\u00f4.\u00a0Con s\u1ed1 \u0111\u00f3 t\u0103ng h\u01a1n g\u1ea5p \u0111\u00f4i sau khi b\u1ed9 gen \u0111\u01b0\u1ee3c gi\u1ea3i tr\u00ecnh t\u1ef1 b\u1eb1ng vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c thu\u1eadt to\u00e1n v\u00e0 \u1ee9ng d\u1ee5ng ph\u1ee9c t\u1ea1p nh\u01b0 H\u1ecdc s\u00e2u v\u00e0 x\u1eed l\u00fd ng\u00f4n ng\u1eef t\u1ef1 nhi\u00ean.<\/p>\n<p>B\u1edfi v\u00ec chi ph\u00ed gi\u1ea3i tr\u00ecnh t\u1ef1 b\u1ed9 gen ng\u01b0\u1eddi ti\u1ebfp t\u1ee5c gi\u1ea3m n\u00ean d\u1eabn \u0111\u1ebfn kh\u1ed1i l\u01b0\u1ee3ng d\u1eef li\u1ec7u gi\u1ea3i tr\u00ecnh t\u1ef1 \u0111ang t\u0103ng theo c\u1ea5p s\u1ed1 nh\u00e2n.<\/p>\n<p>\u01af\u1edbc t\u00ednh\u00a0s\u1ebd c\u1ea7n kho\u1ea3ng\u00a040 exabyte \u0111\u1ec3 l\u01b0u tr\u1eef t\u1ea5t c\u1ea3 d\u1eef li\u1ec7u b\u1ed9 gen c\u1ee7a con ng\u01b0\u1eddi v\u00e0o n\u0103m 2025. Dung l\u01b0\u1ee3ng \u0111\u00f3 g\u1ea5p 8 l\u1ea7n so v\u1edbi dung l\u01b0\u1ee3ng c\u1ea7n thi\u1ebft \u0111\u1ec3 l\u01b0u tr\u1eef m\u1ecdi t\u1eeb \u0111\u01b0\u1ee3c n\u00f3i trong l\u1ecbch s\u1eed lo\u00e0i ng\u01b0\u1eddi.<\/p>\n<p>Nhi\u1ec1u quy tr\u00ecnh ph\u00e2n t\u00edch b\u1ed9 gen \u0111ang\u00a0ph\u1ea3i v\u1eadt l\u1ed9n \u0111\u1ec3 theo k\u1ecbp\u00a0m\u1ee9c \u0111\u1ed9 m\u1edf r\u1ed9ng c\u1ee7a d\u1eef li\u1ec7u th\u00f4 \u0111\u01b0\u1ee3c t\u1ea1o ra.<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/thegioimaychu.vn\/blog\/wp-content\/uploads\/2023\/02\/tgmc-blog-63f9956a04df7.png\" alt=\"\" \/><\/p>\n<h2>C\u00e1c quy tr\u00ecnh\u00a0ph\u00e2n t\u00edch gi\u1ea3i tr\u00ecnh t\u1ef1 gen \u0111\u01b0\u1ee3c t\u0103ng t\u1ed1c<\/h2>\n<p>Ph\u00e2n t\u00edch gi\u1ea3i tr\u00ecnh t\u1ef1 l\u00e0 r\u1ea5t ph\u1ee9c t\u1ea1p v\u00e0 chuy\u00ean s\u00e2u v\u1ec1 t\u00ednh to\u00e1n, v\u1edbi nhi\u1ec1u b\u01b0\u1edbc c\u1ea7n thi\u1ebft \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh c\u00e1c bi\u1ebfn th\u1ec3 di truy\u1ec1n trong b\u1ed9 gen c\u1ee7a con ng\u01b0\u1eddi.<\/p>\n<p>H\u1ecdc s\u00e2u \u0111ang tr\u1edf n\u00ean quan tr\u1ecdng \u0111\u1ed1i v\u1edbi base calling ngay trong c\u00f4ng c\u1ee5 b\u1ed9 gen b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c m\u00f4 h\u00ecnh d\u1ef1a tr\u00ean m\u1ea1ng n\u01a1-ron t\u00edch ch\u1eadp (CNN) v\u00e0 d\u1ef1a tr\u00ean RNN.\u00a0M\u1ea1ng n\u01a1-ron nh\u00e2n t\u1ea1o (neural network) di\u1ec5n gi\u1ea3i d\u1eef li\u1ec7u h\u00ecnh \u1ea3nh v\u00e0 t\u00edn hi\u1ec7u do c\u00e1c c\u00f4ng c\u1ee5 t\u1ea1o ra v\u00e0 suy lu\u1eadn ra 3 t\u1ef7 c\u1eb7p nucleotide c\u1ee7a b\u1ed9 gen ng\u01b0\u1eddi.\u00a0\u0110i\u1ec1u n\u00e0y \u0111ang c\u1ea3i thi\u1ec7n \u0111\u1ed9 ch\u00ednh x\u00e1c c\u1ee7a c\u00e1c l\u1ea7n \u0111\u1ecdc v\u00e0 \u0111\u1ea3m b\u1ea3o r\u1eb1ng base calling di\u1ec5n ra g\u1ea7n v\u1edbi th\u1eddi gian th\u1ef1c h\u01a1n, \u0111\u1ea9y nhanh h\u01a1n n\u1eefa to\u00e0n b\u1ed9 quy tr\u00ecnh nghi\u00ean c\u1ee9u h\u1ec7 gen h\u1ecdc, t\u1eeb m\u1eabu \u0111\u1ebfn variant call format (VCF) cho \u0111\u1ebfn b\u00e1o c\u00e1o cu\u1ed1i c\u00f9ng.<\/p>\n<p>\u0110\u1ed1i v\u1edbi ph\u00e2n t\u00edch b\u1ed9 gen th\u1ee9 c\u1ea5p, c\u00e1c c\u00f4ng ngh\u1ec7 c\u0103n ch\u1ec9nh s\u1eed d\u1ee5ng m\u1ed9t b\u1ed9 gen tham chi\u1ebfu \u0111\u1ec3 h\u1ed7 tr\u1ee3 gh\u00e9p b\u1ed9 gen l\u1ea1i v\u1edbi nhau sau khi gi\u1ea3i tr\u00ecnh t\u1ef1 c\u00e1c \u0111o\u1ea1n DNA.<\/p>\n<p><a href=\"https:\/\/docs.nvidia.com\/clara\/parabricks\/4.0.0\/Documentation\/ToolDocs\/man_fq2bam.html#man-fq2bam\" target=\"_blank\" rel=\"noopener\">BWA-MEM<\/a>, m\u1ed9t thu\u1eadt to\u00e1n h\u00e0ng \u0111\u1ea7u \u0111\u1ec3 c\u0103n ch\u1ec9nh, \u0111ang gi\u00fap c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u l\u1eadp b\u1ea3n \u0111\u1ed3 nhanh ch\u00f3ng c\u00e1c l\u1ea7n \u0111\u1ecdc tr\u00ecnh t\u1ef1 DNA cho m\u1ed9t b\u1ed9 gen tham chi\u1ebfu.\u00a0<a href=\"https:\/\/docs.nvidia.com\/clara\/parabricks\/4.0.0\/Documentation\/ToolDocs\/man_starfusion.html#man-starfusion\" target=\"_blank\" rel=\"noopener\">STAR<\/a>\u00a0l\u00e0 m\u1ed9t thu\u1eadt to\u00e1n c\u0103n ch\u1ec9nh ti\u00eau chu\u1ea9n v\u00e0ng kh\u00e1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho d\u1eef li\u1ec7u gi\u1ea3i tr\u00ecnh t\u1ef1 RNA mang l\u1ea1i kh\u1ea3 n\u0103ng c\u0103n ch\u1ec9nh ch\u00ednh x\u00e1c, c\u1ef1c nhanh \u0111\u1ec3 hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 c\u00e1c bi\u1ec3u hi\u1ec7n gen.<\/p>\n<p>Thu\u1eadt to\u00e1n l\u1eadp tr\u00ecnh \u0111\u1ed9ng Smith-Waterman c\u0169ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i \u0111\u1ec3 c\u0103n ch\u1ec9nh, m\u1ed9t b\u01b0\u1edbc \u0111\u01b0\u1ee3c t\u0103ng t\u1ed1c g\u1ea5p 35 l\u1ea7n tr\u00ean GPU\u00a0<a href=\"https:\/\/www.nvidia.com\/en-us\/data-center\/technologies\/hopper-architecture\/\" target=\"_blank\" rel=\"noopener\">NVIDIA H100 Tensor Core<\/a>, bao g\u1ed3m m\u1ed9t b\u1ed9 t\u0103ng t\u1ed1c l\u1eadp tr\u00ecnh \u0111\u1ed9ng.<\/p>\n<p><iframe loading=\"lazy\" title=\"Optimizing an Ultrarapid DNA Sequencing Technique for Critical Care Patients\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/dnKJTaYoAh8?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<h2>Kh\u00e1m ph\u00e1\u00a0c\u00e1c bi\u1ebfn th\u1ec3 di truy\u1ec1n<\/h2>\n<p>M\u1ed9t trong nh\u1eefng giai \u0111o\u1ea1n quan tr\u1ecdng nh\u1ea5t c\u1ee7a c\u00e1c d\u1ef1 \u00e1n gi\u1ea3i tr\u00ecnh t\u1ef1 l\u00e0 variant calling, trong \u0111\u00f3 c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u x\u00e1c \u0111\u1ecbnh s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa m\u1eabu c\u1ee7a b\u1ec7nh nh\u00e2n v\u00e0 b\u1ed9 gen tham chi\u1ebfu.\u00a0\u0110i\u1ec1u n\u00e0y gi\u00fap c\u00e1c b\u00e1c s\u0129 l\u00e2m s\u00e0ng x\u00e1c \u0111\u1ecbnh b\u1ec7nh di truy\u1ec1n m\u00e0 m\u1ed9t b\u1ec7nh nh\u00e2n b\u1ec7nh n\u1eb7ng c\u00f3 th\u1ec3 m\u1eafc ph\u1ea3i ho\u1eb7c gi\u00fap c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u xem x\u00e9t to\u00e0n b\u1ed9 d\u00e2n s\u1ed1 \u0111\u1ec3 ph\u00e1t tri\u1ec3n c\u00e1c lo\u1ea1i thu\u1ed1c m\u1edbi.\u00a0Nh\u1eefng bi\u1ebfn th\u1ec3 n\u00e0y c\u00f3 th\u1ec3 l\u00e0 c\u00e1c thay \u0111\u1ed5i nucleotide \u0111\u01a1n, c\u00e1c ch\u1ec9nh s\u1eeda nh\u1ecf ho\u1eb7c c\u00e1c s\u1ef1 s\u1eafp x\u1ebfp ph\u1ee9c t\u1ea1p.<\/p>\n<p>C\u00e1c tr\u00ecnh g\u1ecdi \u0111\u01b0\u1ee3c t\u0103ng t\u1ed1c v\u00e0 t\u1ed1i \u01b0u h\u00f3a b\u1edfi GPU, ch\u1eb3ng h\u1ea1n nh\u01b0 <a href=\"https:\/\/gatk.broadinstitute.org\/hc\/en-us\">Broad Institute\u2019s GATK<\/a>\u00a0&#8211; b\u1ed9 c\u00f4ng c\u1ee5 ph\u00e2n t\u00edch b\u1ed9 gen d\u00e0nh cho germline variant calling &#8211; t\u0103ng t\u1ed1c \u0111\u1ed9 ph\u00e2n t\u00edch.\u00a0\u0110\u1ec3 gi\u00fap c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u lo\u1ea1i b\u1ecf d\u01b0\u01a1ng t\u00ednh gi\u1ea3 trong c\u00e1c k\u1ebft qu\u1ea3 GATK, NVIDIA \u0111\u00e3 h\u1ee3p t\u00e1c v\u1edbi Broad Institute \u0111\u1ec3 gi\u1edbi thi\u1ec7u\u00a0<a href=\"https:\/\/gatk.broadinstitute.org\/hc\/en-us\/articles\/10064202674971-Introducing-NVIDIA-s-NVScoreVariants-a-new-deep-learning-tool-for-filtering-variants-\">NVScoreVariants<\/a>, m\u1ed9t c\u00f4ng c\u1ee5 H\u1ecdc s\u00e2u \u0111\u1ec3 l\u1ecdc c\u00e1c bi\u1ebfn th\u1ec3 b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c CNN.<\/p>\n<p>C\u00e1c tr\u00ecnh g\u1ecdi bi\u1ebfn th\u1ec3 d\u1ef1a tr\u00ean H\u1ecdc s\u00e2u nh\u01b0\u00a0<a href=\"https:\/\/docs.nvidia.com\/clara\/parabricks\/4.0.0\/Documentation\/ToolDocs\/man_deepvariant.html#man-deepvariant\" target=\"_blank\" rel=\"noopener\">DeepVariant<\/a>\u00a0c\u1ee7a Google t\u0103ng \u0111\u1ed9 ch\u00ednh x\u00e1c c\u1ee7a c\u00e1c l\u1ea7n g\u1ecdi m\u00e0 kh\u00f4ng c\u1ea7n b\u01b0\u1edbc l\u1ecdc ri\u00eang.\u00a0DeepVariant s\u1eed d\u1ee5ng ki\u1ebfn \u200b\u200btr\u00fac CNN \u0111\u1ec3 g\u1ecdi c\u00e1c bi\u1ebfn th\u1ec3.\u00a0N\u00f3 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111\u00e0o t\u1ea1o l\u1ea1i \u0111\u1ec3 tinh ch\u1ec9nh nh\u1eb1m t\u0103ng \u0111\u1ed9 ch\u00ednh x\u00e1c v\u1edbi c\u00e1c output c\u1ee7a t\u1eebng n\u1ec1n t\u1ea3ng b\u1ed9 gen.<\/p>\n<p>Ph\u1ea7n m\u1ec1m ph\u00e2n t\u00edch th\u1ee9 c\u1ea5p trong b\u1ed9 c\u00f4ng c\u1ee5\u00a0<a href=\"https:\/\/www.nvidia.com\/en-us\/clara\/genomics\/\" target=\"_blank\" rel=\"noopener\">NVIDIA Clara Parabricks<\/a>\u00a0\u0111\u00e3 t\u0103ng t\u1ed1c c\u00e1c tr\u00ecnh g\u1ecdi bi\u1ebfn th\u1ec3 n\u00e0y\u00a0l\u00ean t\u1edbi 80 l\u1ea7n.\u00a0V\u00ed d\u1ee5: th\u1eddi gian ch\u1ea1y c\u1ee7a ph\u1ea7n m\u1ec1m germline HaplotypeCaller gi\u1ea3m t\u1eeb 16 gi\u1edd trong m\u00f4i tr\u01b0\u1eddng d\u1ef1a tr\u00ean CPU xu\u1ed1ng c\u00f2n ch\u01b0a \u0111\u1ebfn 5 ph\u00fat v\u1edbi Clara Parabricks \u0111\u01b0\u1ee3c t\u0103ng t\u1ed1c b\u1edfi GPU.<\/p>\n<h2>T\u0103ng t\u1ed1c l\u00e0n s\u00f3ng ti\u1ebfp theo c\u1ee7a H\u1ec7 gen h\u1ecdc<\/h2>\n<p>NVIDIA \u0111ang gi\u00fap k\u00edch ho\u1ea1t l\u00e0n s\u00f3ng H\u1ec7 gen h\u1ecdc ti\u1ebfp theo b\u1eb1ng c\u00e1ch h\u1ed7 tr\u1ee3 cho c\u1ea3 hai n\u1ec1n t\u1ea3ng gi\u1ea3i tr\u00ecnh t\u1ef1 \u0111\u1ecdc ng\u1eafn v\u00e0 d\u00e0i v\u1edbi base calling v\u00e0 variant calling \u0111\u01b0\u1ee3c t\u0103ng t\u1ed1c AI.\u00a0C\u00e1c c\u00f4ng ty kh\u1edfi nghi\u1ec7p v\u00e0 h\u00e0ng \u0111\u1ea7u ng\u00e0nh \u0111ang h\u1ee3p t\u00e1c v\u1edbi NVIDIA \u0111\u1ec3 m\u1edf r\u1ed9ng ranh gi\u1edbi c\u1ee7a ho\u1ea1t \u0111\u1ed9ng gi\u1ea3i tr\u00ecnh t\u1ef1 to\u00e0n b\u1ed9 gen.<\/p>\n<p>C\u00f4ng ty c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u00a0<a href=\"https:\/\/www.pacb.com\/\" target=\"_blank\" rel=\"noopener\">PacBio<\/a>\u00a0g\u1ea7n \u0111\u00e2y \u0111\u00e3 c\u00f4ng b\u1ed1 h\u1ec7 th\u1ed1ng\u00a0<a href=\"https:\/\/www.pacb.com\/press_releases\/pacbio-announces-revio-a-revolutionary-new-long-read-sequencing-system-designed-to-provide-15-times-more-hifi-data-and-human-genomes-at-scale-for-under-1000\/\" target=\"_blank\" rel=\"noopener\">Revio<\/a>, m\u1ed9t h\u1ec7 th\u1ed1ng gi\u1ea3i tr\u00ecnh t\u1ef1 \u0111\u1ecdc d\u00e0i m\u1edbi v\u1edbi c\u00e1c GPU NVIDIA Tensor Core.\u00a0\u0110\u01b0\u1ee3c h\u1ed7 tr\u1ee3 b\u1edfi s\u1ee9c m\u1ea1nh t\u00ednh to\u00e1n t\u0103ng g\u1ea5p 20 l\u1ea7n so v\u1edbi c\u00e1c h\u1ec7 th\u1ed1ng tr\u01b0\u1edbc \u0111\u00f3, Revio \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 gi\u1ea3i tr\u00ecnh t\u1ef1 b\u1ed9 gen ng\u01b0\u1eddi v\u1edbi c\u00e1c l\u1ea7n \u0111\u1ecdc d\u00e0i c\u00f3 \u0111\u1ed9 ch\u00ednh x\u00e1c cao \u1edf quy m\u00f4 l\u1edbn v\u1edbi chi ph\u00ed d\u01b0\u1edbi 1.000 USD.<\/p>\n<p><a href=\"https:\/\/nanoporetech.com\/\" target=\"_blank\" rel=\"noopener\">Oxford Nanopore Technologies<\/a>\u00a0cung c\u1ea5p c\u00f4ng ngh\u1ec7 \u0111\u01a1n l\u1ebb duy nh\u1ea5t c\u00f3 th\u1ec3 gi\u1ea3i tr\u00ecnh t\u1ef1 c\u00e1c \u0111o\u1ea1n DNA ho\u1eb7c RNA c\u00f3 \u0111\u1ed9 d\u00e0i b\u1ea5t k\u1ef3 theo th\u1eddi gian th\u1ef1c.\u00a0Nh\u1eefng t\u00ednh n\u0103ng n\u00e0y cho ph\u00e9p ph\u00e1t hi\u1ec7n nhanh ch\u00f3ng nhi\u1ec1u bi\u1ebfn th\u1ec3 di truy\u1ec1n h\u01a1n.\u00a0B\u1ec7nh vi\u1ec7n Nhi \u0111\u1ed3ng Seattle g\u1ea7n \u0111\u00e2y \u0111\u00e3 s\u1eed d\u1ee5ng c\u00f4ng c\u1ee5 gi\u1ea3i tr\u00ecnh t\u1ef1 l\u1ed7 nano th\u00f4ng l\u01b0\u1ee3ng cao PromethION \u0111\u1ec3 t\u00ecm hi\u1ec3u v\u1ec1 r\u1ed1i lo\u1ea1n di truy\u1ec1n trong v\u00e0i gi\u1edd \u0111\u1ea7u c\u1ee7a tr\u1ebb s\u01a1 sinh.<\/p>\n<p><a href=\"https:\/\/www.ultimagenomics.com\/\" target=\"_blank\" rel=\"noopener\">Ultima Genomics<\/a>\u00a0\u0111ang cung c\u1ea5p d\u1ecbch v\u1ee5 gi\u1ea3i tr\u00ecnh t\u1ef1 to\u00e0n b\u1ed9 gen th\u00f4ng l\u01b0\u1ee3ng cao ch\u1ec9 v\u1edbi 100 \u0111\u00f4 la cho m\u1ed7i m\u1eabu v\u00e0\u00a0<a href=\"https:\/\/singulargenomics.com\/\">G4 c\u1ee7a\u00a0Singular Genomics<\/a> l\u00e0 h\u1ec7 th\u1ed1ng m\u00e1y t\u00ednh \u0111\u1ec3 b\u00e0n m\u1ea1nh m\u1ebd nh\u1ea5t.<\/p>\n<h2>T\u00ecm hi\u1ec3u th\u00eam<\/h2>\n<p>T\u1ea1i\u00a0<a href=\"https:\/\/bit.ly\/ntc-gtc\" target=\"_blank\" rel=\"noopener\">NVIDIA GTC<\/a>, m\u1ed9t h\u1ed9i ngh\u1ecb AI mi\u1ec5n ph\u00ed di\u1ec5n ra tr\u1ef1c tuy\u1ebfn t\u1eeb ng\u00e0y 20 \u0111\u1ebfn ng\u00e0y 23 th\u00e1ng 3, c\u00e1c di\u1ec5n gi\u1ea3 t\u1eeb PacBio, Oxford Nanopore, Genomic England, KAUST, Stanford, Argonne National Labs v\u00e0 c\u00e1c t\u1ed5 ch\u1ee9c h\u00e0ng \u0111\u1ea7u kh\u00e1c s\u1ebd chia s\u1ebb <a href=\"https:\/\/register.nvidia.com\/flow\/nvidia\/gtcspring2023\/attendeeportal\/page\/sessioncatalog?tab.catalogallsessionstab=16566177511100015Kus&amp;search.topic=1652219616233002cRyq\">nh\u1eefng ti\u1ebfn b\u1ed9 m\u1edbi nh\u1ea5t c\u1ee7a AI trong gi\u1ea3i tr\u00ecnh t\u1ef1, ph\u00e2n t\u00edch h\u1ec7 gen h\u1ecdc<\/a>\u00a0v\u00e0 c\u00e1c m\u00f4 h\u00ecnh ng\u00f4n ng\u1eef l\u1edbn\u00a0\u0111\u1ec3 hi\u1ec3u v\u1ec1 bi\u1ec3u hi\u1ec7n gen.<\/p>\n<p>H\u1ed9i ngh\u1ecb c\u00f3 <a href=\"https:\/\/www.nvidia.com\/gtc\/keynote\/\">b\u00e0i\u00a0ph\u00e1t bi\u1ec3u quan tr\u1ecdng<\/a> c\u1ee7a ng\u01b0\u1eddi s\u00e1ng l\u1eadp ki\u00eam Gi\u00e1m \u0111\u1ed1c \u0111i\u1ec1u h\u00e0nh c\u1ee7a NVIDIA &#8211; Jensen Huang\u00a0v\u00e0o th\u1ee9 Ba, ng\u00e0y 21 th\u00e1ng 3, l\u00fac 8 gi\u1edd s\u00e1ng theo gi\u1edd Th\u00e1i B\u00ecnh D\u01b0\u01a1ng.<\/p>\n<p><a href=\"https:\/\/www.nvidia.com\/en-us\/clara\/genomics\/\" target=\"_blank\" rel=\"noopener\">NVIDIA Clara Parabricks<\/a>\u00a0mi\u1ec5n ph\u00ed \u0111\u1ec3 t\u1ea3i xu\u1ed1ng.\u00a0<a href=\"https:\/\/www.nvidia.com\/en-us\/clara\/genomics\/free-trial-vs-buy\/\" target=\"_blank\" rel=\"noopener\">T\u00ecm hi\u1ec3u<\/a>\u00a0ho\u1eb7c\u00a0d\u00f9ng th\u1eed <a href=\"https:\/\/www.nvidia.com\/en-us\/launchpad\/ai\/accelerated-genomic-analysis-with-clara-parabricks\/\">hands-on lab<\/a> mi\u1ec5n ph\u00ed\u00a0\u0111\u1ec3 tr\u1ea3i nghi\u1ec7m ho\u1ea1t \u0111\u1ed9ng c\u1ee7a b\u1ed9 c\u00f4ng c\u1ee5 n\u00e0y.<\/p>\n<div>____<br \/><b>B\u00e0i vi\u1ebft li\u00ean quan<\/b><\/div>\n<ul>\n<li><a href=\"https:\/\/thegioimaychu.vn\/blog\/?post_type=post&#038;p=21370\">Khoa h\u1ecdc \u0111\u1eddi s\u1ed1ng: Khi \u0111\u1ed9t ph\u00e1 n\u1eb1m trong bi\u1ec3n d\u1eef li\u1ec7u v\u00e0 ch\u00eca kh\u00f3a mang t\u00ean h\u1ea1 t\u1ea7ng AI<\/a><\/li>\n<li><a href=\"https:\/\/thegioimaychu.vn\/blog\/?post_type=post&#038;p=18937\">NVIDIA CEO: \u2018N\u0103m nay, m\u1ecdi ng\u00e0nh c\u00f4ng nghi\u1ec7p s\u1ebd tr\u1edf th\u00e0nh ng\u00e0nh c\u00f4ng ngh\u1ec7\u2019<\/a><\/li>\n<li><a href=\"https:\/\/thegioimaychu.vn\/blog\/?post_type=post&#038;p=18761\">11 c\u00e1ch m\u00e0 AI gi\u00fap th\u1ebf gi\u1edbi t\u1ed1t \u0111\u1eb9p h\u01a1n trong n\u0103m 2023<\/a><\/li>\n<li><a href=\"https:\/\/thegioimaychu.vn\/blog\/?post_type=post&#038;p=18456\">NVIDIA cung c\u1ea5p MONAI d\u01b0\u1edbi d\u1ea1ng d\u1ecbch v\u1ee5 \u0111\u00e1m m\u00e2y: H\u1ed7 tr\u1ee3 m\u1ea1nh m\u1ebd cho Medical Imaging<\/a><\/li>\n<li><a href=\"https:\/\/thegioimaychu.vn\/blog\/?post_type=post&#038;p=17990\">AI \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 th\u1ebf n\u00e0o trong ng\u00e0nh y t\u1ebf v\u00e0 nghi\u00ean c\u1ee9u Gen<\/a><\/li>\n<li><a href=\"https:\/\/thegioimaychu.vn\/blog\/?post_type=post&#038;p=15317\">NVIDIA Clara: T\u0103ng t\u1ed1c nghi\u00ean c\u1ee9u v\u00e0 \u1ee9ng d\u1ee5ng AI trong l\u0129nh v\u1ef1c y t\u1ebf<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Tr&iacute; tu&#7879; nh&acirc;n t&#7841;o (AI) v&agrave; &#273;i&#7879;n to&aacute;n t&#259;ng t&#7889;c &#273;ang m&#7903; ra nh&#7919;ng kh&#7843; n&#259;ng m&#7899;i trong quy tr&igrave;nh gi&#7843;i tr&igrave;nh t&#7921; gen. 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C&aacute;c ch&#432;&#417;ng tr&igrave;nh h&#7879;&#8230;<\/p>\n","protected":false},"author":29,"featured_media":14782,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[3,1],"tags":[1016,1015,1013,416,1014,787],"class_list":["post-14741","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ai-hpc","category-tong-hop","tag-bioinformatics","tag-genome-sequencing","tag-genomics","tag-healthcare","tag-life-science","tag-social-impact"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>AI \u0111ang l\u00e0m thay \u0111\u1ed5i ng\u00e0nh Gen h\u1ecdc nh\u01b0 th\u1ebf n\u00e0o? - Blog | TheGioiMayChu<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/thegioimaychu.vn\/blog\/ai-hpc\/ai-dang-bien-doi-he-gen-hoc-nhu-the-nao-p14741\/\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"AI \u0111ang l\u00e0m thay \u0111\u1ed5i ng\u00e0nh Gen h\u1ecdc nh\u01b0 th\u1ebf n\u00e0o? - Blog | TheGioiMayChu\" \/>\n<meta name=\"twitter:description\" content=\"Tr&iacute; tu&#7879; nh&acirc;n t&#7841;o (AI) v&agrave; &#273;i&#7879;n to&aacute;n t&#259;ng t&#7889;c &#273;ang m&#7903; ra nh&#7919;ng kh&#7843; n&#259;ng m&#7899;i trong quy tr&igrave;nh gi&#7843;i tr&igrave;nh t&#7921; gen. 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